Regional Truck Driving Jobs In Missouri

Missouri
Regional truck driver beside a semi-truck in Missouri

Discover great opportunities for regional truck driving jobs in Missouri, where central U.S. location and strong highway access keep freight moving all year long.

  • Missouri drivers enjoy high demand along I-70, I-44, and I-55 freight corridors.
  • Most regional routes offer weekly or even multiple home days per week.
  • Top hiring cities include St. Louis, Kansas City, and Springfield.
  • Local fleets handle consumer goods, agriculture, and manufacturing freight.
  • Stable routes and rising wages make Missouri ideal for both new and experienced CDL drivers.

Drive Your Career Forward in Missouri

From metro hubs to rural routes, regional CDL jobs in Missouri offer consistent schedules, solid pay, and opportunities for long-term growth. Drive with leading carriers that value your time and experience.

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Click below to view the latest regional CDL job openings across Missouri.

Regional Truck Driving Jobs in Missouri Cities

Regional Truck Driving in Maryland Heights

Available Regional Truck Driving Jobs in Missouri

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Class A OTR/Regional Drivers Out 21 Days-Home 7 Days-100%-No Touch-90-112K/Yr

Quick Transport

Posted: 2025-07-03

Branson, Missouri $90,000 - $112,000 a year OTR
Build your career with a reputable company offering excellent incentive pay, PTO, BCBS medical and dental plans, and a 401K. Drive the latest models of Cascadias, Internationals, or Kenworths for professional growth opportunities.
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CDL A Regional Driver - Recent Grads

Butler Transport, Inc

Posted: 2025-07-03

Branson, Missouri $0.60 per mile OTR
Be a part of the reputable Butler team and experience career growth opportunities. Drive consistent routes, with great mileage, and job security. Join us for a professional and rewarding driving career.
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Owner/Operator- Class A CDL Driver- OTR-Regional- Dry Van

Dry Creek Logistics

Posted: 2025-07-03

Branson, Missouri $5,000 - $6,000 a week OTR
Grow your career with our reputable 100% owner-operator company offering regional runs, OTR services, and dedicated customer freight. Enjoy fuel discounts, insurance, and professional development opportunities.
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Owner Operator Truck Driver Regional & Local OTR Loads

NRL Carrier

Posted: 2025-07-03

Branson, Missouri $7,000 a week OTR
NRL Carrier, a locally owned logistics company, prioritizes driver satisfaction with high-paying loads and a respectful work environment. With opportunities for career growth and professional development, drivers can thrive in a diverse and multilingual team.
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CL A Dedicated Regional Home W/Ends-1750-2800/WK

The Wick Transport

Posted: 2025-05-20

St. Louis, Missouri $0.70 - $0.80 per mile OTR
Join a reputable company with opportunities for career growth. Drive modern trucks, earn competitive pay, and enjoy a comprehensive benefits package after 60 days.
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CDL-A Drivers: Get Pay Protection on Regional Runs + Home Weekends!

Millis Transfer

Posted: 2025-05-20

St. Louis, Missouri $1,600 a week OTR
Millis Transfer, a multi-safety award winner, offers career growth opportunities, professional development, and a strong company reputation in the trucking industry.
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Car Hauler * Good Home Time * Preferred Lanes * MO Regional

JMN Transportation Inc

Posted: 2025-05-20

Maryland Heights, Missouri $75,000 - $80,000 a year OTR
JMN offers a reputable company culture with opportunities for career growth and professional development. Join their supportive family and take your career to new heights as a Car Hauler.
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CDL A Regional Drive-No Experience OK

DriveLine Solutions

Posted: 2025-05-20

St. Louis, Missouri $1,400 a week OTR
Grow your career with us as a Class A Regional Driver. Benefit from our strong company reputation, health incentives, and opportunities for professional growth in the transportation industry.
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